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Managing Complex Older Adults With Treatment-Resistant Depression: In-Depth Study Discussion
Credit(s):
0.75 Contact Hour(s) of CE; 0.1 of which may be applied towards Pharmacology
Released: 01/21/2026 Expires: 12/31/2027 11:55 PM CT (subject to change)
CE for this activity will not be available after this date.
This activity includes transcription.
Overview: In this episode of NP Pulse: The Voice of the Nurse Practitioner®, Drs. Eric Lenze and Megan Morgenthaler will discuss evidence-based treatments for older adults living with treatment-resistant depression using the findings from the Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression study. Treatment-resistant depression is a form of major depressive disorder that has not responded to at least two antidepressant treatments.
This activity is an Accredited AANP Podcast Activity. Learners will need to listen to the podcast through their preferred podcast provider (Search for "NP Pulse" and listen to Episode 170).A participation code will be given at the END of the podcast - make sure to write this code down. Once you've listened to the podcast and have the participation code, return to this activity in the CE Center. Click on the "Next Steps" button of the activity and (1) enter the participation code that was provided, (2) complete the post-test, and (3) complete the activity evaluation. This will award your CE credit and certificate of completion.
Objectives
Define treatment-resistant depression in older adults.
Describe how to use medication augmentation/switching for treatment-resistant depression.
Explain one approach to deprescribing medications for older adults.
Speakers Eric Lenze, MD Megan Morgenthaler, DNP, PMHNP Disclosure This program was planned in accordance with AANP CE Standards and Policies.
The speakers for this activity have the following disclosures:
Eric Lenze
Research Support (non-government)
Emergent Ventures FastGrants
Balvi
Consultant
None in the past two years
I own no stocks or equity in any pharmaceutical company
Megan Morgenthaler
Nothing to disclose.
All relevant financial relationships have been mitigated. This session developed as part of the AANP Clinical Effectiveness Research Initiative (CERi), funded by Eugene Washington PCORI’s Engagement Award (EADI #35224). Views/opinions expressed herein do not necessarily reflect views/positions of AANP/PCORI.
Disclaimer Individuals who have contributed to the CE Center were carefully selected for their knowledge and experience in the subject area under review. This presentation is informational only and may contain opinions of the authors from their personal experience that do not necessarily express the opinions of the American Association of Nurse Practitioners (AANP). The activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Clinical practice is a constantly changing process and new information becomes available every day. Neither AANP nor the contributing individuals can warrant that the material will continue to be accurate, nor do they warrant that the material is completely free of errors upon publication. Attendees and participants should appraise the information presented critically and are encouraged to consult appropriate resources for any product or device mentioned in this program. CE Credit Instructions
Readthisactivitydescription,includingobjectives and disclosures.
Completetheeducationalcontent:
AANP Podcast: Click the Play button to be taken to the NP Pulse podcast on Podbean. If you have a different podcast provider that you prefer, launch your preferred podcast app and search for "NP Pulse".
Listen to all of Episode 170. A participation code will be provided at the end. Make sure to write this code down! You will need this code to unlock access the the post-test and evaluation to complete the activity to earn your CE credit. The code will consist of a LETTERS and NUMBERS. When entering the code in the Participation Code field, make sure you enter the letters and numbers together (no space between them). Letters are not case sensitive.
Return to the AANP CE Center. Click on the activity from your CE Activities list and then click the blue Next Steps button:
A new window will open. Provide and submit the Participation Code, exactly as it was given at the end of the podcast, in the available text field.
Submit the activity evaluation to receive full AANP CE/Rx credit and your certificate of completion.
Additional Information For questions or more information concerning this online CE activity,please visit the AANP Help Center to find answers to frequently asked questions and request assistance.
0.75 Contact Hour(s) of CE, 0.1 of which may be applied towards Pharmacology
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