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Improving Patient-Centric Care with Novel Therapies in Ulcerative Colitis
Activity includes Podcast and AANP Clinical Brief
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Released: 05/14/2025
Expires: 05/31/2026 (subject to change)
- CE for this activity will not be available after this date.
 | This activity includes transcription. |
Overview
This activity includes a podcast and a clinical brief. Learners can choose to complete either or both activities for credit. CE credit will be awarded individually for each activity completed. - Podcast Overview: In NP Pulse Podcast Episode 148, nurse practitioners Jessica Crimaldi and Christina Hanson explore the evolving landscape of ulcerative colitis (UC), a chronic inflammatory bowel disease affecting over a million Americans. With decades of GI experience, Jessica and Christina break down the burden of UC on patients’ physical and psychosocial well-being, review distinguishing features from Crohn’s disease, and examine the increasing prevalence tied to lifestyle and environmental factors. This important conversation dives into the era of precision medicine, highlighting a new generation of targeted therapies, updated clinical guidelines, and best practices for early diagnosis, management, and shared decision-making. From understanding disease severity and medication classes to addressing extraintestinal manifestations, cancer screening, and vaccination recommendations, this episode is a must-listen for NPs striving to provide optimal, up-to-date care for patients with ulcerative colitis.
- Clinical Brief Overview: The clinical brief activity offers an in-depth, evidence-based overview of the evolving landscape of ulcerative colitis (UC) management, with a particular emphasis on the nurse practitioner’s role in delivering patient-centered care. It begins by contextualizing UC as a chronic, immune-mediated inflammatory bowel disease with rising incidence, especially among young adults, and highlights the profound physical, emotional, and social burdens faced by patients. The document explores the pathophysiology of UC, including epithelial barrier dysfunction and immune dysregulation, and outlines how these insights have shaped the development of advanced therapies, including biologics, small molecules, and precision medicine strategies. Emphasizing shared decision-making (SDM), the Brief presents current guidelines, comparative drug profiles, and considerations for therapy selection based on disease severity, treatment history, and patient preferences. Through illustrative case studies and clinical tools, it equips nurse practitioners with the knowledge to navigate complex treatment choices, personalize care, and improve outcomes in moderate-to-severe UC.
Objectives
- Discuss the epidemiology, pathophysiology, and patient-centric burden of ulcerative colitis (UC).
- Examine how an improved understanding of UC pathogenesis and progression has driven recent advancements in the evolving and expanding treatment armamentarium.
- Evaluate the clinical trial evidence in support of novel pharmacotherapeutics in UC management, with a focus on S1PR modulators, JAK inhibitors, and biologic mAbs aimed at the IL-12/23 axis.
- Design individualized UC treatment plans that integrate evidence, expert consensus, and patient-specific and disease-specific factors using shared decision-making.
Speakers
Jessica Crimaldi, MSN, NP-C, CMSRN
Christina Hanson, FNP-C
Disclosure
This program was planned in accordance with AANP CE Standards and Policies.
The speakers have the following disclosures:- Jessica Crimaldi
- Advisory Board for Madrigal Pharmaceuticals (Fatty liver disease)
- Christina Hanson
- No relevant financial relationships
All Planners involved in this activity have no relevant financial relationships to disclose.
All relevant financial relationships have been mitigated.
The podcast for this program has been supported by an educational grant from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC. The clinical brief for this program has been supported by an independent medical education grant from AbbVie Inc.
Disclaimer
Individuals who have contributed to the CE Center were carefully selected for their knowledge and experience in the subject area under review. This presentation is informational only and may contain opinions of the authors from their personal experience that do not necessarily express the opinions of the American Association of Nurse Practitioners (AANP). The activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Clinical practice is a constantly changing process and new information becomes available every day. Neither AANP nor the contributing individuals can warrant that the material will continue to be accurate, nor do they warrant that the material is completely free of errors upon publication. Attendees and participants should appraise the information presented critically and are encouraged to consult appropriate resources for any product or device mentioned in this program.
CE Credit Instructions- Read this activity description, including objectives and disclosures.
- Complete the educational content:
- Podcast:
- Click the Play button to be taken to the NP Pulse podcast on Podbean. If you have a different podcast provider that you prefer, launch your preferred podcast app and search for "NP Pulse".
- Listen to all of Episode 148. A participation code will be provided at the end. Make sure to write this code down! You will need this code to unlock access the the post-test and evaluation to complete the activity to earn your CE credit. The code will consist of a LETTERS and NUMBERS. When entering the code in the Participation Code field, make sure you enter the letters and numbers together (no space between them). Letters are not case sensitive.
- Click on the Additional Resources button to review all additional materials provided (handouts, post-test reviews, any other downloadable resources).
- Return to the AANP CE Center. Click on the activity from your CE Activities list and then click the blue Next Steps button:
- A new window will open. Provide and submit the Participation Code, exactly as it was given at the end of the podcast, in the available text field.
- Complete the post-test.
- Submit the activity evaluation to receive full AANP CE/Rx credit and your certificate of completion.
- Clinical Brief:
- Complete the Pretest associated with this part of the activity
- Click the Play button to get access to the downloadable PDF clinical brief of the activity. Learners will be required to read all presented material in the PDF.
- Click on the Additional Resources button to review all additional materials provided (handouts, post-test reviews, any other downloadable resources).
- After completing all content, click on the blue Next Steps button:
- Submit the affidavit statement.
- Complete the post-test.
- Submit the evaluation to receive continuing education credit.
Additional Information
For questions or more information concerning this online CE activity, please visit the AANP Help Center to find answers to frequently asked questions and request assistance.
2 Contact Hour(s) of CE,
1.5 of which may be applied towards Pharmacology
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